Equilibrium of Heterogeneous Congestion Control: Optimality and Stability

When heterogeneous congestion control protocols that react to different pricing signals share the same network, the current theory based on utility maximization fails to predict the network behavior. The pricing signals can be different types of signals such as packet loss, queueing delay, etc, or different values of the same type of signal such as different ECN marking values based on the same actual link congestion level. Unlike in a homogeneous network, the bandwidth allocation now depends on router parameters and flow arrival patterns. It can be non-unique, suboptimal and unstable. In Tang et al. (“Equilibrium of heterogeneous congestion control: Existence and uniqueness,” IEEE/ACM Trans. Netw., vol. 15, no. 4, pp. 824–837, Aug. 2007), existence and uniqueness of equilibrium of heterogeneous protocols are investigated. This paper extends the study with two objectives: analyzing the optimality and stability of such networks and designing control schemes to improve those properties. First, we demonstrate the intricate behavior of a heterogeneous network through simulations and present a framework to help understand its equilibrium properties. Second, we propose a simple source-based algorithm to decouple bandwidth allocation from router parameters and flow arrival patterns by only updating a linear parameter in the sources’ algorithms on a slow timescale. It steers a network to the unique optimal equilibrium. The scheme can be deployed incrementally as the existing protocol needs no change and only new protocols need to adopt the slow timescale adaptation

Method and apparatus for network congestion control

The present invention is a delay based model and in fact uses queuing delay as a congestion measure, providing advantages over prior art loss based systems. One advantage is that queuing delay can be more accurately estimated than loss probability. This is because packet losses in networks with large bandwidth-delay product are rare events under TCP Reno and its variants (probability on the order 10.sup.-7 or smaller), and because loss samples provide coarser information than queuing delay samples. Indeed, measurements of delay are noisy, just as those of loss probability. Thus, another advantage of the present invention is that each measurement of queuing delay provides multi-bit information while each measurement of packet loss (whether a packet is lost) provides only one bit of information for the filtering of noise. This makes it easier for an equation-based implementation to stabilize a network into a steady state with a target fairness and high utilization. In addition, the dynamics of queuing delay provides scaling with respect to network capacity. This helps maintain stability as a network scales up in capacity

Method and apparatus for network congestion control

The present invention is a delay based model and in fact uses queuing delay as a congestion measure, providing advantages over prior art loss based systems. One advantage is that queuing delay can be more accurately estimated than loss probability. This is because packet losses in networks with large bandwidth-delay product are rare events under TCP Reno and its variants (probability on the order 10.sup.-7 or smaller), and because loss samples provide coarser information than queuing delay samples. Indeed, measurements of delay are noisy, just as those of loss probability. Thus, another advantage of the present invention is that each measurement of queuing delay provides multi-bit information while each measurement of packet loss (whether a packet is lost) provides only one bit of information for the filtering of noise. This makes it easier for an equation-based implementation to stabilize a network into a steady state with a target fairness and high utilization. In addition, the dynamics of queuing delay provides scaling with respect to network capacity. This helps maintain stability as a network scales up in capacity

Transcriptomic-metabolomic reprogramming in EGFR-mutant NSCLC early adaptive drug escape linking TGFβ2-bioenergetics-mitochondrial priming.

The impact of EGFR-mutant NSCLC precision therapy is limited by acquired resistance despite initial excellent response. Classic studies of EGFR-mutant clinical resistance to precision therapy were based on tumor rebiopsies late during clinical tumor progression on therapy. Here, we characterized a novel non-mutational early adaptive drug-escape in EGFR-mutant lung tumor cells only days after therapy initiation, that is MET-independent. The drug-escape cell states were analyzed by integrated transcriptomic and metabolomics profiling uncovering a central role for autocrine TGFβ2 in mediating cellular plasticity through profound cellular adaptive Omics reprogramming, with common mechanistic link to prosurvival mitochondrial priming. Cells undergoing early adaptive drug escape are in proliferative-metabolic quiescent, with enhanced EMT-ness and stem cell signaling, exhibiting global bioenergetics suppression including reverse Warburg, and are susceptible to glutamine deprivation and TGFβ2 inhibition. Our study further supports a preemptive therapeutic targeting of bioenergetics and mitochondrial priming to impact early drug-escape emergence using EGFR precision inhibitor combined with broad BH3-mimetic to interrupt BCL-2/BCL-xL together, but not BCL-2 alone

Combined Associations of a Polygenic Risk Score and Classical Risk Factors With Breast Cancer Risk.

We evaluated the joint associations between a new 313-variant PRS (PRS313) and questionnaire-based breast cancer risk factors for women of European ancestry, using 72 284 cases and 80 354 controls from the Breast Cancer Association Consortium. Interactions were evaluated using standard logistic regression and a newly developed case-only method for breast cancer risk overall and by estrogen receptor status. After accounting for multiple testing, we did not find evidence that per-standard deviation PRS313 odds ratio differed across strata defined by individual risk factors. Goodness-of-fit tests did not reject the assumption of a multiplicative model between PRS313 and each risk factor. Variation in projected absolute lifetime risk of breast cancer associated with classical risk factors was greater for women with higher genetic risk (PRS313 and family history) and, on average, 17.5% higher in the highest vs lowest deciles of genetic risk. These findings have implications for risk prevention for women at increased risk of breast cancer

Finishing the euchromatic sequence of the human genome

The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead

Research and Design of a Routing Protocol in Large-Scale Wireless Sensor Networks

无线传感器网络，作为全球未来十大技术之一，集成了传感器技术、嵌入式计算技术、分布式信息处理和自组织网技术，可实时感知、采集、处理、传输网络分布区域内的各种信息数据，在军事国防、生物医疗、环境监测、抢险救灾、防恐反恐、危险区域远程控制等领域具有十分广阔的应用前景。 本文研究分析了无线传感器网络的已有路由协议，并针对大规模的无线传感器网络设计了一种树状路由协议，它根据节点地址信息来形成路由，从而简化了复杂繁冗的路由表查找和维护，节省了不必要的开销，提高了路由效率，实现了快速有效的数据传输。 为支持此路由协议本文提出了一种自适应动态地址分配算——ADAR（AdaptiveDynamicAddre...As one of the ten high technologies in the future, wireless sensor network, which is the integration of micro-sensors, embedded computing, modern network and Ad Hoc technologies, can apperceive, collect, process and transmit various information data within the region. It can be used in military defense, biomedical, environmental monitoring, disaster relief, counter-terrorism, remote control of haz...学位：工学硕士院系专业：信息科学与技术学院通信工程系_通信与信息系统学号：2332007115216

Microscopic Behavior of Internet Congestion Control

The Internet research community has focused on the macroscopic behavior of Transmission Control Protocol (TCP) and overlooked its microscopic behavior for years. This thesis studies the microscopic behavior of TCP and its effects on performance. We go into the packet-level details of TCP control algorithms and explore the behavior in short time scales within one round-trip time. We find that the burstiness effects in such small time scales have significant impacts on both delay-based TCP and loss-based TCP. For delay-based TCP algorithms, the micro-burst leads to much faster queue convergence than what the traditional macroscopic models predict. With such fast queue convergence, some delay-based congestion control algorithms are much more stable in reality than in the analytical results from existing macroscopic models. This observation allows us to design more responsive yet stable algorithm which would otherwise be impossible. For loss-based TCP algorithms, the sub-RTT burstiness in TCP packet transmission process has significant impacts on the loss synchronization rate, an important parameter which affects the efficiency, fairness and convergence of loss-based TCP congestion control algorithms. Our findings explain several long-standing controversial problems and have inspired new algorithms that achieve better TCP performance.</p

Optimizing 10-Gigabit Ethernet for Networks of Workstations, Clusters and Grids: A Case Study

This paper presents a case study of the 10-Gigabit Ethernet (10GbE) adapter from Intel R○. Specifically, with appropriate optimizations to the configurations of the 10GbE adapter and TCP, we demonstrate that the 10GbE adapter can perform well in local-area, storage-area, system-area, and wide-area networks. For local-area, storage-area, and system-area networks in support of networks of workstations, network-attached storage, and clusters, respectively, we can achieve over 7-Gb/s end-to-end throughput and 12-µs end-to-end latency between applications running on Linux-based PCs. For the wide-area network in support of grids, we broke the recently-set Internet2 Land Speed Record by 2.5 times by sustaining an endto-end TCP/IP throughput of 2.38 Gb/s between Sunnyvale